Vascular Lesions and Developmental Changes Produced by Renal Cortical Extract

Abstract

Non-pressor renal vascular injurious factor was injected intra venously to bilaterally nephrectomized rats.
Striking features of endothelial cells in mesenteric and pancreatic arteries responsible for increased permeability, namely, the separations of intercellular junctions and denudation of endothelial layer were observed. In consequence, serous component and ferritin particles, rarely accompained by platelets, erythrocytes and polynuclear leukocytes penetrated into the media, in which fibrin deposits were focally exhibited.
Another study employed the procedure to perform unilateral nephrectomy and contralateral urethral ligation and to remove the ligation 24 hours after the intravenous injection of renal cortical extract so as to privide long survival of rats.
Panarteritis was observed 5-7 days after the renal cortical extract injection and it was sometimes accompained by fibrinoid degeneration.
Proliferation of elastic fibers of the intima and cellulofibrous thickening of the media were observed in some arteries 1-2 months after the renal cortical extract injection.
These changes occured independently from hypertension, immunological factors and abnormality of BUN and urine protein levels.