1978 Volume 6 Issue 1 Pages 67-72
Levels of serum α-tocopherol, lipoperoxide and lipids were studied in acute stage of stroke and MI. Serum α-tocopherol were 0.73±0.43 (n=46) in stroke and 0.72±0.31mg/dl (n=10) in MI within 48 hours of the onset, which were significantly lower than the level of control group (0.99±0.22 mg/dl). Concurrently, the TBARS (TBA reactive substance) denoting the level of the lipoperoxide, were 5.64±2.72 (n=41) in stroke and 5.40±3.16 nmol/ml (n=9) in MI respectively. These were markedly higher than the level of control group (3.22±0.89nmol/ml).
No correlation was seen in serum α-tocopherol and TBARS but serum cholesterol or the ratio of linoleic to oleic acid of FFA was correlated with α-tocopherol in stroke. Along with following studies up to one month, α-tocopherol of most cases of stroke came down to the lowest level early in the 3 to 5 days and therafter recovered gradually. The ratio of α-tocopherol to cholesterol was minimum in early phase and then took a crescendo curve later in two weeks. TBARS increased during the first week in both groups. Finally, a case of MI was presented in whom all of α-tocopherol, TBARS and FFA which had been normal the day before the accident, changed in a steep wise soon after the occurence of the attack. The results imply that α-tocopherol may be consumed, playing a role of the antioxidant against the lipoperoxide which must increase depending on the tissue damage induced by stroke or MI.
