Abstract
On 42 hyperlipidemic out-patients aged 33-69 years, the effects of dietary treatment for five weeks to serum lipoprotein were studied. Two types of diet were designed. Subjects with type IIA were kept on diet low in fat (20% of total carolies) and cholesterol (150mg daily) and high polyunsaturated/saturated (P/S) ratio (3.0). Subjects with type IIB, type III and type IV were given a low carbohydrate diet (40% of carolies) and the same content of cholesterol and P/S ratio.
Three lipoprotein classes were determined with lipoprotein electrophoresis using an internal standard (dyed carbamylated albumin). The diet caused significant reductions on mean levels of α-lipoprotein (8%↓, p<0.05) and β-lipoprotein (10%↓, p<0.05) in type IIA, α-lipoprotein (7%↓, p<0.05), pre β-lipoprotein (35%↓, p<0.01) and β-lipoprotein (14%↓, p<0.01) in type IIB and pre, β-lipoprotein (47%↓, p<0.001) in type IV.
A few cases of type IIA changed into other phenotypes, but type IIB and type IV changed more frequently into other phenotypes.
Of these, 9 hyperlipidemic patients (21%) were normalized in the lipid levels.
