Effects of Y-9738 on low HDL (High-Density Lipoprotein) Cholesterolemia

Abstract

Effects of Y-9738 [ethyl 2-(4-cholorophenyl)-5-ethoxy-4-oxazole acetate] on low HDL cholesterolemia were studied in 18 patients with serum HDL cholesterol(ch) of less than 54mg/dl. Y-9738 was administered at 900mg/day for 4 months, and serum HDL-ch, total-ch and lipoprotein fraction were measured.
The HDL-ch level of 43.3mg/dl (average) before treatment significantly increased (p<0.05) one month after administration, and reached the peak of 56.0mg/dl after 3 months. LDL-ch showed no significant change and HDL-ch/LDL-ch ratio increased from 0.347 to 0.423. the α/β ratio of lipoprotein fraction also increased. Total-ch did not change significantly.