Abstract
The effect of tocofibrate [tocopheryl 2-(p-chlorophenoxy) isobutyrate] on cholesterol level in rats fed high-fat cholesterol diet was studies. Lowering activity of tocofibrate in cholesterol level in blood was no less than that of clofibrate (ED50 of tocofibrate; 98.0μmol/kg or 61.5mg/kg, and clofibrate; 920μmg/kg or 223mg/kg).
To elucidate the mechanism of tocofibrate, intracellular distribution of the compound in liver was investigated. This paper suggested that tocofibrate associated mainly with peroxisomes, and that the distribution clearly differed from both that of clofibrate and α-tocopherol.
