Abstract
Anesthesia and chemotherapy in cats with early CKD can cause acute exacerbation of CKD andacute kidney injury later. However, it is difficult to predict the prognosis with traditional markers.In human studies, renal functional reserve (RFR) is defined as the temporary increase in GFRdue to protein intake, and a method to measure all remaining renal function has been proposed.However, RFR has not been investigated in cats. Since RFR could be a tool for predicting CKDprognosis and AKI risk in cats, this study aimed to establish a method to measure RFR as basicresearch. The measurement conditions were examined using endogenous creatinine clearancein four normal cats. Next, we examined RFR in 10 cats with blood Cre levels less than 1.6 mg/dl. GFR was measured before (baseline GFR) and after (post GFR) protein intake by exogenouscreatinine clearance method. A high-protein food was the final candidate. Post GFR peaked at3.5 h after protein ingestion. An increase in post GFR was observed in 8 of 10 cats, suggestingthat protein intake may increase GFR in cats. However, post GFR decreased in two cats due tofactors other than decreased renal function. A modified condition setting was required. In thefuture, we plan to reexamine the measurement method, and evaluate RFR in cats.
