Abstract
Granulation or cicatrization developing after phonosurgery exerts an extensive influence on postoperative voice. An experimental study was performed to suppress the formation of granulation tissue by the local administration of tranilast, a drug used in treatment of hypertrophic scars.
Methods : To granulation tissues under stimulation induced by 0.5% carrageenin on fresh wound of vocal folds of dog, 2.0% tranilast (tranilast) and liposome-sealed 2% tranilast (liposome-sealed tranilast) were locally administered.
Results : Compared with tranilast, the liposome-sealed tranilast remained in the tissues for a longer time and promoted the suppression of the hyperplasia of granulation tissues. Also, when it was locally administered to a fresh wound on canine vocal folds, satisfactory vibration during phonation was attained after the operation.
Conclusion : Using a local administration of tranilast, a suppression of the hyperplasia of granulation tissue was observed. When tranilast sealed in liposome was given, intra-tissue concentration was maintained, and the suppression of the hyperplasia of granulation was further reinforced.
