A Case of Subglottic Amyloidosis

Abstract

We reported a case of subglottic amyloidosis in the larynx. A 53-year-old female complained of hoarseness and dyspnea. At the first examination, a smooth-surfaced tumor was detected in the subglottic region. We performed a tracheostomy and resected the tumor. Histopathological findings revealed amyloidosis. Systemic amyloidosis was excluded by extensive examinations. Laryngeal amyloidosis is a rare disease, with 125 cases reported to date in the Japanese literature. Only 15 cases with subglottic lesion have been reported. Recently, the main treatment for laryngeal amyloidosis is surgical resection by laryngomicrosurgery (LMS) using laser. The tumor in this case was resected by LMS and coagulated by argon plasma coagulation (APC), with three treatments over a period of four years. After the latest operation, the patient showed a favorable outcome. The findings demonstrate that APC surgery is an effective treatment for laryngeal amyloidosis.