Adipose Tissue Formation in Response to Basic Fibroblast Growth Factor

Abstract

In an effort to prevent loss of fat volume and promote generation of additional adipose tissue after intracordal injection of autologous fat, we evaluate the effect of injecting fat together with basic fibroblast growth factor.
Models of bilateral recurrent laryngeal nerve paralysis were prepared using eight beagle dogs. Autologous fat was injected into one vocal cord, and a mixture of autologous fat with basic fibroblast growth factor, gelatin microspheres, and collagen sponge was injected into the other. When the autologous fat was injected together with bFGF, fusiform immature fat cells were observed in the injected fat tissues. These were not found when the autologous fat was injected in isolation.
These findings suggested that the formation of new fat cells may occur in injected adipose tissue in response to bFGF.