Local Control of Laryngeal Cancer by Radiotherapy and Boron Neutron Capture Therapy (BNCT) for Cases of Local Recurrence

Abstract

Introduction: Many patients with laryngeal cancer desire radical cure and preservation of voice and swallowing function. At our institution, patients with locally recurrent laryngeal cancer who have a strong desire for laryngeal preservation are treated with boron neutron capture therapy (BNCT). Objective: To investigate the efficacy of BNCT for locally recurrent laryngeal cancer after radical irradiation. Patients and Methods: We retrospectively examined the local control rate of BNCT, post-treatment for recurrent lesions after BNCT, and efficacy of BNCT by rcT stage in 28 patients who underwent BNCT for locally recurrent laryngeal cancer after irradiation. Results: The efficacy of BNCT for locally recurrent laryngeal cancer at 3 months was 78.6% for CR, 10.7% for PR, 10.7% for SD, and 0% for PD. The 1-year local control rate was 65.9%. CR rates by rcT stage were 75.0% for rcT1, 75.0% for rcT2, 71.4% for rcT3, and 100% for rcT4. Conclusion: BNCT is expected to be a new treatment option to maintain quality of survival in patients with recurrent laryngeal cancer after radiotherapy who strongly desire laryngeal sparing.