Abstract
Two cases of juvenile laryngeal papillomatosis which have been successively treated with voice rest and Terramycin were reported.
Case I: A boy, aged 3 and half years, was first seen by us in December, 1953, with the chief complaints of hoarseness and dyspnea. His past and family histories were essentially negative and no wart and condyloma acuminatum were seen. A provisional tracheostomy was done to put the larynx at rest. Direct laryngoscopy revealed that the larynx was near entirely filled with papillomatous mass. Irradiation with X-ray was ineffective only to increase the size of the mass. Terramycin was given in two periods, each period being 100 days, and the dosis of daily Terramycin was 250 mg. The papillomatous mass disappeared after the treatment. No evidence of recurrence was seen for 9 years and his voice remains good.
Case 2: A girl, aged 2 years and 10 months, was first seen by us in May, 1957, with a tracheostoma done at the other hospital. Papillomata were seen at the left false cord, at the tracheostoma and the tracheocarina. According to her mother, the patient was hoarse when she was 7 or 8 months old. A tracheostomy and several surgeries to remove the papillomata were done at the other hospital. Terramycin was given without effect. No surgery was attempted by us and she was put under our observation. Many warts appeared at her right hand in 1963. Our observation in 1965 revealed that she had only a small mass of papillomatous tissue at the left false cord. Previous surgeries resulted in scar formation which gave rise to the deformed larynx and hoarseness.
Also discussed in the present report were; two kinds of laryngeal papilloma viruses, the relationship with warts and the effect of antibiotics.
