Abstract
Three patients with aggressive juvenile laryngeal papillomatosis were treated with the combined use of endoscopic laser surgery and systemic administration of alpha-type interferon (Human Lymphoblastoid Interferon). All the three cases had the onset of the disease under four years of age and were of fulminant type with strong tendency of recurrence. The current results were, however, complete disappearance of papilloma in two cases and a tracelike remnant in one case and the control of papilloma was successful.
Since there is no single method of treatment to eradicate laryngeal papilloma in children consistently, it seems necessary to obtain lasting therapeutic effects by combining several kinds of therapeutic methods. It was emphasized that laser surgery and interferon were both powerful therapeutic means for this tenacious disease.
