1985 Volume 36 Issue 2 Pages 100-107
Relationship between the susceptibility to Newcastle disease virus (NDV) and mucociliary function in the chicken nose was studied.
Intranasal inoculations of different amount of virus had similar effect on the mucociliary function, on viral amount recovered from throat swabs and on pathological changes of the chicken turbinate.
The lesions induced by NDV following intranasal inoculation produced a selective destruction of significant portions of the inner surface of the turbinate scroll, but sinus lesions were not common. These results were supported by the amount of virus and the mucociliary transport time in turbinate and sinus.
Deceleration of the mucociliary transport time induced by dehydration did increase the amount of NDV by 100 to 1000 times over the control values. 20% cocaine and atropine had little effect on the mucociliary function 30 minutes after administration, but susceptibility of nasal mucosa decreased about 10 times in cocaine and 100 to 1000 times in atropine. These results indicated that the susceptibility of nasal mucosa to NDV might be actually affected by the mucociliary function.
