Abstract
Sinobronchial syndrome is defined as a coexisting pathology of chronic sinusitis and nonspecific chronic inflammatory lesion of the lower airway (e. g. chronic bronchitis, bronchiectasis, and diffuse panbronchiolitis).
The cases of sinobronchial syndrome were found in 10.4% of 309 patients with chronic sinusitis, and in 55.4% of 74 patients with chronic lower respiratory infectious diseases. In many cases of sinobronchial syndrome, the time lag between the onset of nasal symptoms and that of bronchial ones was found. The nasal symptoms had appeared in childhood and bronchial symptoms had appeared after adolescence. The clinical courses in 20 cases with sinobronchial syndrome were observed after the radical operation to chronic sinusitis. The results of treatment were not satisfactory especially as far as their bronchial symptoms were concerned (only three cases were improved).
Sinobronchial syndrome, especially diffuse panbronchiolitis was significantly associated with HLA-Bw54, which was found specifically in Japanese and not in Caucasians. These facts may suggest that there is a gene controlling the susceptibility to sinobronchial syndrome, especially diffuse panbronchiolitis.
