Bronchial Asthma and Immune Responses in the Respiratory Mucosa

Yuji Tohda; Hirokazu Kubo; Rie Urakami; Hiroshi Nakahara; Masato Muraki; Masahiro Fukuoka; Shigenori Nakajima

doi:10.2468/jbes.48.84

Yuji Tohda, Hirokazu Kubo, Rie Urakami, Hiroshi Nakahara, Masato Muraki, Masahiro Fukuoka, Shigenori Nakajima

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Keywords: bronchial asthma, immune responses in respiratory mucosa, T cells, eosinophil, epithelial cells

JOURNAL FREE ACCESS

1997 Volume 48 Issue 2 Pages 84-90

DOI https://doi.org/10.2468/jbes.48.84

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Abstract

We studied respiratory mucosa immune responses in bronchial asthma using guinea pigs and human respiratory epithelial cells. In asthma models (guinea pigs), CD4⁺ T cells enhanced LAR, and CD8⁺ T cells inhibited LAR after antigen inhalation. Regulatory effects of IL-5 and ICAM-1 on LAR were detected. PAF enhanced the adhesion of human respiratory epithelial cells and eosinophils. TNF-α stimulated the production of GM-CSF in human respiratory epithelial cells, while TGF-β₁ depressed human eosinophil survival.

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