Inhibition of HIV-1 Reverse Transcriptase Activity  by Brasenia schreberi (Junsai) Components

Tetsuro Hisayoshi; Mayu Shinomura; Atsushi Konishi; Junji Tanaka; Hiroshi Shimoda; Keishi Hata; Saori Takahashi; Kiyoshi Yasukawa

doi:10.14533/jbm.14.59

Inhibition of HIV-1 Reverse Transcriptase Activity by Brasenia schreberi (Junsai) Components

Tetsuro Hisayoshi, Mayu Shinomura, Atsushi Konishi, Junji Tanaka, Hiroshi Shimoda, Keishi Hata, Saori Takahashi, Kiyoshi Yasukawa

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Keywords: Brasenia schreberi, HIV-1, inhibition, reverse transcriptase

JOURNAL OPEN ACCESS

2014 Volume 14 Issue 1 Pages 59-65

DOI https://doi.org/10.14533/jbm.14.59

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Abstract

We screened for inhibitory activities of 25 wild vegetables and fruits for human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Among them, ethanol- and water-extracts of Brasenia schreberi (Junsai) and water-extract of Petasites japonicus (Fuki) strongly inhibited the HIV-1 RT activity to incorporate dTTP into poly(rA)-p(dT)15. We tested HIV-1 RT inhibitory activities of 15 polyphenols, isolated from Brasenia schreberi. Among them, gossypetin and hypolaetin 7-O-glucoside inhibited the activity.

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