Abstract
To verify the proposal that the administration of phosphate stimulates the secretion of PTH, a bone activator, 5 patients with osteoporosis were treated with phosphate and calcitonin. PTH secretion increased markedly in response to the treatment with phosphate. Calcitonin was administered intermittently to depress bone absorption. After 6 months treatment, histological examinations in 2 patients showed significantly active changes, absorption and formation, in bone areas, although the bone area was increased in one patients and reduced in the other. The discrepancy of this finding may be due to the technique for bone biopsy. Thus the principle of the present treatment agrees with ADFR treatment proposed by Frost and contributes a beneficial effect in the therapy of osteoporosis.
