Abstract
Osteoporosis was induced in adult rats by oophorectomy. The tibial cortical thickness was then measured radiologically following the treatment with active vitamin D, 1, 25(OH)2D3, for 12 weeks at the daily dose of 0.05 to 3.00μg/rat, 1.25(OH)2D3 increased the periosteal diameter and decreased the endosteal diameter. In the microradiographic evaluation, bone resorption was observed in the intracortical bone associated with periosteal new bone formation. Size-corrected fat-free dry bone weight (W/LD) was increased in dose-dependent.
It suggests that 1, 25(OH)2D3 is useful for the treatment of postmenopausal osteoporosis.
