Abstract
The effect of Ipriflavone (TC-80) on bone resorption, caused by transplanted parathyroid glands (PT) in contact with the periosteum of the parietal bone of a rat, was studied.
The number of osteoclasts and the amount of bone resorption showed a significant increase on the 3rd and 7th day after PT transplant. Pretreatments of TC-80 (100mg/kg/day and 500mg/kg/day) significantly suppressed the increase in the number of osteoclasts and the amount of bone resorption brought about by PT transplant. Suppression was more marked in rats which received 500mg/kg of TC-80. These date demonstrate that TC-80 supressed the osteoclastic bone resorption.
