Abstract
Cultured epithelial autografts have been used for the treatment of extensive burns; however, such treatments often fail because of wound infection or mechanical deviation. Thus, the use of proper primary dressing is important for engraftment. Herein, we report treatment of extensive burns using a dialkylcarbamoyl chloride (DACC) -coated dressing as the primary dressing of cultured epidermis.
A 75-year-old patient sustained burns on the head, face, back, and limbs. Thirty-one BPD, we performed debridement, and transplantation of cultured epidermis and meshed autografts (ratio 3:1). We covered the patient with DACC-coated dressing. When we removed the DACC-coated dressing on the 7th postoperative day, cultured epidermis and meshed autografts had survived.
DACC-coated dressing irreversibly binds to pathogenic microorganisms by hydrophobic interaction and inactivates them. This effect lasts for up to 7 days. Our findings suggest that DACC-coated dressing is effective for infection prevention in cultured epidermis transplant regions.
