A 5-HT_2A Receptor Antagonist, Sarpogrelate Hydrochloride, Improves the Microcirculation in Patients with Peripheral Arterial Disease

Abstract

We assessed whether sarpogrelate hydrochloride improves the microcirculation in patients with peripheral artery disease, by measuring the transcutaneous oxygen tension (tcPO₂). The tcPO₂ was measured in the dorsum pedis of 13 patients before and after 2 weeks of sarpogrelate hyrochloride treatment (300 mg/day). The 26 legs were classified into 2 groups: those with a tcPO₂ (A) <50 mmHg and those >50 mmHg (B). There were significant difference in the findings noted before administration and those between the first treatment and 2 weeks into therapy. There were significant differences in the findings between before and after administration in the first treatment. These findings suggest that sarpogrelate hydrochloride improves the microcirculation in legs with a tcPO₂ <50 mmHg.