The Pathological Findings, after the Injection of Periodontal Bacteria Had Induced Chronic-phase Thrombus, are Similar to the Pathology Changes in Early Atherosclerotic Aorta or Arterial Atheroma

Abstract

The development and proceeding of atherosclerosis is based on chronic inflammatory changes. We injected 3 kinds of popular periodontal bacteria into the lightly ligated external iliac arteries of 31 mice. We then obtained 22 pieces of arterial thrombus and selected the same number of chronic-phase specimens for study. We then compared the early phase of human atherosclerosis of the aorta and the atheroma in the advanced atherosclerosis cases with each other pathologically. We observed the presence of lymphocytes, macrophages, and T cells (CD3) in both materials, mostly. These findings show that animal models and human specimens are both based on chronic inflammation and suggest the presence of an acquired immunity mechanism, which is probably related to primary immunity by Gram negative bacteria such as oral bacteria.