Abstract
For the early detection of temporal lobe epilepsy and prognosis, the hippocampus is targeted in the diagnosis by positron emission tomography using fluorodeoxyglucose (FDG-PET). The PET image is superior to know the functional information; however, it is hard to distinguish small structures. One of the methods to analyze PET images structurally is statistical analysis by the anatomical standardization. In this standardization, non-linear transformation is used to fit each brain structures to the template. Due to the non-linear transformation, especially in the case of relatively small structures, there is a possibility that displacement errors occur. In this study, after extracting the hippocampal region using a magnetic resonance imaging (MRI), MR images and PET images are registered using rigid transformation, the relationship between glucose metabolism and the subject’s age and sex were investigated. As a result, the decrease in hippocampal volume due to the nomal aging was observed. In addition, the difference due to aging is found in gender., The women have a gradual downward trend in the volume and metabolism. Compared normal subject’s group with epilepsy patients, the difference are found both in volume and metabolism.
