Inhibitory and Inducing Effects of Astaxanthin on CYP

Abstract

This study was aimed to evaluate the inhibitory effect of astaxanthin on 7 types of CYP enzymes (CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) by using human liver microsomes and to evaluate the inducing effect of astaxanthin on 3 types of CYP (CYP1A2, CYP2B6 and CYP3A4) by using cryopreserved human hepatocytes. Resuts indicated that astaxanthin does not inhibit CYP enzymes within the normal doses and astaxanthin does not induce CYP enzymes within the normal doses.