Effects of Dietary Apple Polyphenol on Alcohol-induced Dyslipidemia in Obese Zucker Rats

Abstract

Objectives: We studied the effects of the apple polyphenol (AP) with added alcohol on the weight of accumulated fat and dyslipidemia in obese (fa/fa) Zucker rats. Methods: The Zucker fatty rats of 5weeks male were fed for 4 weeks with the experimental diets used high cholesterol diet with 10% alcohol. The fatty rats were divided Control group and AP group. The control group without apple polyphenol, AP group was that there apple polyphenol. It was measured the posterior abdominal wall fat and testicle peripheral fat weight, the concentrations of serum and liver lipids. Results: The posterior abdominal wall fat weight indicated a tendency to decrease in the AP group compared to the Control group. The concentrations of serum total cholesterol and triglyceride decreased in the AP group compared to the Control group. There was no different between each group with respect to the concentration of cholesterol and triglyceride in the liver. The alanine aminotransferase decreased in the AP group compared to the Control group. Conclusion: These results suggested that the alcohol diets containing the apple polyphenol appear to effectively decrease the concentration of serum lipids and the alanine aminotransferase. The apple polyphenol were expected to prevent dyslipidemia and fatty liver.