Japanese Journal of Complementary and Alternative Medicine
Online ISSN : 1348-7930
Print ISSN : 1348-7922
ISSN-L : 1348-7922
Review
Java Ginger Bangle
Nobutaka SUZUKI , Hoko KYO, Kazuo UEBABA
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Keywords: Java ginger bangle, neurotrophin-mimic active compound, banglene, dementia, MCI (Mild Cognitive Impairment), MoCA-J
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2019 Volume 16 Issue 1 Pages 1-6

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Abstract
The review reveals latest studies of Bangle that has unique ingredients, safety, healthy effect and especially neurotrophin activity. Banglenes have some neurotrophin activity such as neuritogenesis without NGF in vitro, property that enhances hippocampal neurogenesis and crosses the blood-brain barrier (BBB) in vivo. On the other hand, Java ginger bangle (Extract) improves spatial learning in Senescence-Accelerated Mouse. Moreover the human clinical trial for MCI (Mild Cognitive Impairment) have been just started.
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