ハトムギ熱水抽出物のラット急性毒性試験

林 浩孝; 太田 康之; 新井 隆成; 島野 康子; 高野 文英; STRONG Jeffry Michael; 榎本 俊樹; 上馬塲 和夫; 太田 富久; 鈴木 信孝

doi:10.1625/jcam.6.105

Original Article

Acute Oral Toxicity Test of Hot Water Extract of Coix lacryma-jobi L. var. ma-yuen Stapf in Rats

Hirotaka HAYASHI, Yasuyuki OHTA, Takanari ARAI, Yasuko SHIMANO, Fumihide TAKANO, Jeffry Michael STRONG, Toshiki ENOMOTO, Kazuo UEBABA, Tomihisa OHTA, Nobutaka SUZUKI

Author information

Hirotaka HAYASHI
Center for Innovation, Kanazawa University
Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University
Yasuyuki OHTA
Graduate School of Natural Science and Technology, Kanazawa University
Takanari ARAI
Endowed Center for the Advancement of Pregnancy, Perinatal and Infant Care, Kanazawa University Graduate School of Medical Science
Yasuko SHIMANO
Graduate School of Natural Science and Technology, Kanazawa University
Fumihide TAKANO
Graduate School of Natural Science and Technology, Kanazawa University
Jeffry Michael STRONG
Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University
Toshiki ENOMOTO
Department of Food Science, Ishikawa Prefectural University
Kazuo UEBABA
Department of Presymptomatic Health Promotion Institute of Natural Medicine, University of Toyama
Tomihisa OHTA
Graduate School of Natural Science and Technology, Kanazawa University
Nobutaka SUZUKI
Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University

Keywords: Coix lacryma-jobi L. var.ma-yuen Stapf, Coix seed, adlay, acute oral safety test, rat

JOURNAL FREE ACCESS

2009 Volume 6 Issue 2 Pages 105-110

DOI https://doi.org/10.1625/jcam.6.105

Details

Abstract

Coix lacryma-jobi L. var.ma-yuen Stapf (Coix seed) is a grass crop that has long been used in traditional medicine as a nourishing food. However, high-intake safety of the extract of the husks, pellicles and astringent skin of Coix seed has rarely been evaluated. We performed a safety test of hot water extract of all parts of Coix seed (CRD extract) in rats. CRD extract showed no significant toxicity on body weight, blood analyses, urinalysis and histopathological examination in acute toxicity tests.

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