Abstract
Objective: We studied the effect of food consumption and exercise training (EX) on the oxidative stress regulation system and exercise capacity in mice.
Methods: As subjects of this study, we used 46 male mice, which were classified randomly into four groups: one that consumed the reduced coenzyme Q10 (H2CoQ10: QH), one that consumed QH and took EX, one that took EX, and a control group. All the groups were set to keep running to their limit on a treadmill for animals. We measured the exercise capacity (running time) of each group at the beginning and after three, six, and nine months of this study. For the oxidative stress regulation system, we used reactive oxygen and free radical analysis equipment at the beginning and 6 months later of this study. We measured plasma oxidative stresses (d-ROM test) and plasma anti-oxidant potential (BAP test) to calculate the ratio of d-ROM to BAP. After nine months of this study we measured plasma anti-oxidants (ANTI-ROM test), values of plasma QH and plasma Q10 to calculate the reduced ratio.
Result: As a short-term effect of exercise capacity, prolonged running time were recognized by a combination of QH consumption and EX, and as a long-term effect, prolonged running time was recognized by QH consumption. For the oxidative stress regulation system, d-ROM test and ANTI-ROM test did not show any effect of QH consumption or combination of QH consumption and EX. However an elevated value was indicated in the reduced ratio by a combination of QH consumption and EX.
Conclusion: This study has revealed that a combination of QH consumption and EX has an effect on exercise capacity and the oxidative stress regulation system such as reduced ratio.
