Enhancement of Enantioselectivity by Altering Alcohol Concentration for Esterification in Supercritical CO2

Jau-Yann Wu; Ming-Tsai Liang

doi:10.1252/jcej.32.338

Biochemical, Food and Medical

Enhancement of Enantioselectivity by Altering Alcohol Concentration for Esterification in Supercritical CO₂

Jau-Yann Wu, Ming-Tsai Liang

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Keywords: Enantioselectivity Enhancement, Enzymatic Resolution, Substrate, Cosolvent, Supercritical Carbon Dioxide

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1999 Volume 32 Issue 3 Pages 338-340

DOI https://doi.org/10.1252/jcej.32.338

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Abstract

This work used Candida rugosa lipase to resolve racemic Naproxen by esterification with ethanol, n-butanol, n-hexanol or n-decanol in supercritical CO₂. It was found that the lipase enantioselectively esterified (S)-Naproxen within all systems. The enantiomeric ratio increased four folds by slightly decreasing the alcohol concentration. The effect of the alcohol concentration on the enantioselectivity was greater than that of changing acyl acceptors.

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