Drug Concentration–Time Profile in the Plasma Following the Dissolution-Type Transdermal Delivery

Abstract

In medical treatment, a constant plasma concentration for an extended period of time is preferable for some diseases, while pulsatile delivery or delayed delivery is also required to avoid the tolerance and set a delayed time for medication. The dissolution-type TTS is expected to achieve pulsatile delivery. In this work, a mathematical model was proposed for the prediction of the plasma concentration–time profile following the application of the dissolution-type TTS. In vivo animal data was compared with the simulated profile together with the model parameters determined independently. The calculated concentration–time profile well agreed with the in vivo animal data.