Evaluation of Reslurry Rate for Particle Design of Spherical Crystalline Agglomerates via Crystallization

Abstract

Removing the mother liquor from crystalline agglomerated particles is important to improve crystal quality. Reslurry is one of the operation methods for replacing the mother liquor and recovering purity. The properties of agglomerated crystalline particles are modified by crystallization, which affect the reslurry rate. There are no reported studies on the design of the crystallization process for improving the reslurry rate. The effects of the properties of crystalline agglomerates exerted by the anti-solvent crystallization process on the reslurry rate are discussed. The reslurry was performed using particles of various sizes prepared by controlling the agitation speed during crystallization. The removal ratio was calculated to evaluate the relationship between the properties of the crystalline agglomerates and the reslurry rate. Kinetic studies revealed that the reslurry rate was dependent on the particle size. Thus, a design strategy involving the modification of particle properties in crystallization for improving the reslurry rate is proposed.