MATHEMATICAL MODELING OF TRANSDERMAL DRUG DELIVERY

Abstract

A dynamic mathematical model for transdermal drug delivery is developed on the basis of the bi-layer skin/twocompartment body model. The effects of metabolism reaction in the viable skin, the drug binding and reservoir function in the stratum corneum, and the solubility and diffusivity of the drug in the skin on the permeation ratetime profile are extensively simulated. The effects of the pharmacokinetic parameters on the plasma concentration profile are also analyzed. The present model is useful not only for analyzing the rate of skin permeation but also for predicting the plasma concentration after transdermal drug delivery.