Journal of the Ceramic Society of Japan
Online ISSN : 1348-6535
Print ISSN : 1882-0743
ISSN-L : 1348-6535
Regular Issue: Special Articles: The 73rd CerSJ Awards for Advancements in Ceramic Science and Technology: Review
The development of novel calcium phosphate–polymer composite biomaterials with macro- to nano-level controlled hierarchical structures
Taishi YOKOI
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2019 Volume 127 Issue 10 Pages 715-721


The synthetic technique to control hierarchical structure is essential for the development of highly functional materials. In this article, we review the challenges involved in creating new calcium phosphate–polymer composites as artificial bone that extends beyond autologous bone, by combining hierarchical structural control at the macro, micro, and nano levels. Gel-mediated processing is a powerful method for preparing macroscopically homogeneous calcium phosphate–polymer composites, and the biomimetic approach is effective for controlling the microscopic morphologies of calcium phosphate particles formed in polymeric hydrogel matrices. Octacalcium phosphate (OCP), which is a member of the calcium phosphate family, has a layered structure. Controlling the nanoscopic structure of OCP through the incorporation of organic molecules into the interlayers of its crystal lattice is a promising approach for adding new functionalities and improving the biological properties of composite materials.

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© 2019 The Ceramic Society of Japan
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