Abstract
The diencephalo-pituitary axis is a key center in the endocrine system and plays a critical role in the maintenance of homeostasis. Hormone replacement therapy in the patients after diencephalo-pituitary tumor surgery, especially with hydrocortisone and levothyroxine must need to be tailored to the individuals, ideally based on body surface area- and/or body weight-adjusted regimen. In addition, replacement with GH and gonadotropin should be strongly considered to improve quality of life and various metabolic disorderes.