Normalization of Cardiac Function after Transsphenoidal Surgery in an Acromegalic Patient with Acromegalic Cardiomyopathy : A Case Report

Abstract

A 54-year-old male presented with orthopnea. His illness was diagnosed as dilated cardiomyopathy (DCM) on an ultrasonic cardiograph (UCG). He was sent to our hospital, and admitted to the cardiovascular systems department. He had acromegalic features and a complete medical examination was performed. He was found to have a high level of growth hormone (GH) and a pituitary adenoma on MRI of the brain. His cardiac function abnormality was caused by a GH producing pituitary adenoma. He underwent transsphenoidal surgery. The level of GH and insulin-like growth factor-1 (IGF-1) fell after tumor removal. His symptoms immediately improved and his cardiac function gradually improved. His cardiothoracic ratio (CTR) and ejection fraction (EF) normalized after 5 months post-operation. Tumor removal resulted improved cardiac function with the normalization of GH level.