Abstract
Fifty years have passed since Parkinson's disease was first treated with levodopa. And in the last twenty years, various therapeutic tools including dopamine receptor agonists have been approved. Moreover, it has been revealed that Parkinson's disease includes so-called non-motor symptoms such as autonomic symptoms, cognitive impairment and sleep disturbance and so on, based on degeneration of the amine neuron system, which also results in the Parkinsonian tetrad : rigidity, tremor, akinesia and postural instability. This paper includes a history of the therapies used to treat Parkinson's disease from the start to the present as well as an overview of drug therapy commencement, the initial medication selection, non-motor symptoms and a look at possible future therapies for Parkinson's disease.
