頭部外傷におけるバイオマーカーの有用性と今後の展望

横堀 將司; 山口 昌紘; 藤木 悠; 五十嵐 豊; 橋詰 哲広; 井上 泰豪; 恩田 秀賢; 布施 明; 横田 裕行

doi:10.7887/jcns.23.973

SPECIAL ISSUES Visionary Approach to Neurotrauma

Biomarker for Traumatic Brain Injury and Neurointensive Care : Its Scientific Efficacy and Prospects

Shoji Yokobori, Masahiro Yamaguchi, Yu Fujiki, Yutaka Igarashi, Akihiro Hashizume, Yasuhide Inoue, Hidetaka Onda, Akira Fuse, Hiroyuki Yokota

Author information

Shoji Yokobori
Department of Emergency and Critical Care Medicine, Graduate School of Nippon Medical School
Masahiro Yamaguchi
Department of Emergency and Critical Care Medicine, Graduate School of Nippon Medical School
Yu Fujiki
Department of Emergency and Critical Care Medicine, Graduate School of Nippon Medical School
Yutaka Igarashi
Department of Emergency and Critical Care Medicine, Graduate School of Nippon Medical School
Akihiro Hashizume
Department of Emergency and Critical Care Medicine, Graduate School of Nippon Medical School
Yasuhide Inoue
Department of Emergency and Critical Care Medicine, Graduate School of Nippon Medical School
Hidetaka Onda
Department of Emergency and Critical Care Medicine, Graduate School of Nippon Medical School
Akira Fuse
Department of Emergency and Critical Care Medicine, Graduate School of Nippon Medical School
Hiroyuki Yokota
Department of Emergency and Critical Care Medicine, Graduate School of Nippon Medical School

Keywords: biomarker, differential diagnosis, intracranial hypertension, pathophysiology, traumatic brain injury

JOURNAL OPEN ACCESS

2014 Volume 23 Issue 12 Pages 973-980

DOI https://doi.org/10.7887/jcns.23.973

Details

Abstract

With the innovation of measuring techniques, research into several biomarker has been ongoing in neurocritical care. In addition to the usual biomarkers such as neuron specific enolase, S100β and glutamate, several new biomarkers along with their pathomechanisms have been studied in traumatic brain injury (TBI) patients. These biomarkers are neurofilament families derived from neural cytoskeleton, tau protein derived from dendritic microtubules, microtubule-associated protein 2 derived from dendritic cell body, myelin basic protein from oligodendrocyte and myelin, ubiquitin C-terminal hydrolase-L1 derived from neural cells and glial fibrillary acidic protein from glial cells.
In this article, we will review the basic and clinical data of these biomarkers. Then, we will discuss the efficacy of these biomarkers for the “visualization” of TBI pathophysiology.

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