Cerebral Venous Sinus Thrombosis due to Congenital Antithrombin Deficiency in the Mother and Neonate for the Same Period

Abstract

  Venous sinus thrombosis is a relatively rare disease, and hereditary coagulopathy is a known risk factor. We report a venous sinus thrombosis that developed in the mother and child after birth and for the same period and whose etiology was subsequently diagnosed by genetic tests as congenital antithrombin deficiency. In addition to the low level of antithrombin activity, other clinical findings obtained during the course of the disease, such as family history of venous thrombosis and heparin inactivity, were important leads for the diagnosis. Although venous sinus thrombosis is relatively rare, we should look for blood coagulation abnormalities, because heparin, the standard treatment drug for thrombosis, is ineffective in patients with antithrombin deficiency.