A Case of Multiple Arterial Stenoses due to Long-term Nilotinib Exposure

Abstract

  Peripheral arterial occlusive disease is one of the adverse events associated with the use of tyrosine kinase inhibitors (TKIs) for treating chronic myelogenous leukemia. Here, we report a case of multiple arterial stenoses due to long-term treatment with nilotinib, a second-generation TKI. The patient was diagnosed with chronic myelogenous leukemia at 31 years of age. The patient was taking TKIs for over 15 years since the age of 35. Cerebral angiography revealed multiple stenotic lesions in the thoracic and cervical regions ; hence, TKI was discontinued, and percutaneous balloon dilation was performed for severe stenosis at the origin of the left vertebral artery. Awareness among clinicians regarding the possibility of multiple arterial stenoses caused by nilotinib when treating stroke is necessary.