2022 Volume 31 Issue 3 Pages 189-194
Papillary glioneuronal tumor (PGNT) is a new type of tumor proposed in 1998. According to the 2007 World Health Organization classification of the central nervous system, PGNT is classified as a mixed glioneuronal tumor. Only 100 cases have been reported worldwide, and its mechanism is still unclear.
We report the case of a 28-year-old woman with a PGNT. Her symptoms were headache only. Magnetic resonance image of the head revealed a 74mm cystic mass in the right temporal lobe. A nodular lesion with contrast effects was observed. The tumor was completely resected. Histologically, a single layer of cells appeared to be lining around the hyalinized blood vessels, forming pseudopapillary structures, and immunostaining was positive for glial fibrillary acidic protein, S-100, and nestin. Proliferating cells were found between the pseudopapillary structures, and synaptophysin and neuron-specific enolase were positive. After surgery, the patient had no recurrence for 2 years. Patients with PGNT should be carefully followed because of previous reports of recurrence incidence.
