2022 Volume 31 Issue 4 Pages 247-252
Mycosis fungoides (MF) is a T cell lymphoma of the skin that leads to systemic inflammation due to nonspecific inflammatory responses against tumor cells. Here, we describe the case of a 57-year-old woman with subarachnoid hemorrhage (SAH) due to the rupture of an anterior communicating artery aneurysm during MF treatment. She was diagnosed with MF 2 years ago and received molecular-targeted drug administration and regional radiation therapy for MF several times for 2 years. Immediately before the additional treatment for MF progression, she presented with sudden headache and disturbance of consciousness. Head computed tomography (CT) /CT angiography revealed SAH due to the rupture of an anterior communicating artery aneurysm ; subsequently, she underwent aneurysm coil embolization. After coil embolization, the patient experienced no obvious cerebral vasospasm. However, 8 months later, the patient died of sepsis during MF treatment. To the best of our knowledge, this is the first report of SAH associated with MF. Recently, it has been revealed that chronic inflammation is closely related to the pathogenesis of cerebral aneurysm development and rupture. Moreover, it has been reported that infiltration of T lymphocytes into the intracranial vessel walls induces aneurysm rupture. We assume that systemic inflammation due to MF was involved in the rupture of the cerebral aneurysm in this case.
