A Case of Diffuse Hemispheric Glioma, H3 G34-mutant with PNET-like Glioblastoma Pathology

Abstract

  In certain cases, high-grade tumors arising in the cerebral hemispheres of young adults contain H3F3A G34R/V mutations.

  A 24-year-old woman was referred to our hospital following a tonic seizure. MRI resonance imaging revealed a mass lesion in the left frontal lobe. Preoperative radiological examinations revealed embryonal tumors and high-grade gliomas as differential diagnoses, Subsequently, craniotomy was performed. Histologically, the tumor was characteristic of glioblastoma with PNET-like morphology. Additional pyrosequencing and Sanger sequencing identified the H3.3 G34R mutation and led to a definitive diagnosis of diffuse hemispheric glioma, with the H3 G34-mutant.