Polymyositis associated with Primary Cerebral Malignant Lymphoma: A Case Report

Abstract

We present the case of a 70-year-old man with polymyositis associated with primary cerebral lymphoma, who was hospitalized for evaluation of headaches, dizziness and visual disturbance. Imaging studies revealed an enhanced cerebral mass. Following treatment with steroids, the mass regressed. However, the patient was subsequently readmitted 22 months later, and histologic analysis of a biopsy specimen confirmed a diagnosis of large-cell lymphoma. Approximately 23 months following his initial presentation, the patient developed muscle weakness and atrophy. A muscle biopsy specimen revealed polymyositis. Despite therapy, the patient died within I month. To our knowledge, this is the first reported case of polymyositis associated with primary cerebral lymphoma.