Abstract
Two gene therapy approaches were studied for the treatment of malignant glioma ; a)suicide gene therapy using the herpes simplex virus-thymidine kinase (HS-tk) gene and ganciclovir, and b)immuno-gene therapy using cytokine gene. In the case of suicide gene therapy, Oldfield et al. started it at the National Institute of Health in the USA and reported its safety and efficacy in 1997. In this paper, further developments of gene therapy for brain tumor are summarized, including the development of gene transfer vectors.
