ラットデキストラン硫酸誘発潰瘍性大腸炎モデルに対するSodium ferrous citrateの抗炎症効果

秦 政輝; 華 見; 北村 大介; 前多 力; 北島 政幸; 笠巻 伸二; 坂本 一博; 落合 匠; 長岡 功; 鎌野 俊紀

doi:10.3862/jcoloproctology.60.1

Original Articles

The Effects of Sodium Ferrous Citrate (SFC) on Dextran Sulfate Sodium (DSS)-Induced Colitis Model in Rats

M. Hata, J. Hua, D. Kitamura, T. Maeda, M. Kitajima, S. Kasamaki, K. Sakamoto, T. Ochiai, I. Nagaoka, T. Kamano

Author information

M. Hata
Department of Coloproctological Surgery, Juntendo University School of Medicine
J. Hua
Department of Host Defense and Biochemical Research, Juntendo University School of Medicine
D. Kitamura
Department of Coloproctological Surgery, Juntendo University School of Medicine
T. Maeda
Department of Coloproctological Surgery, Juntendo University School of Medicine
M. Kitajima
Department of Coloproctological Surgery, Juntendo University School of Medicine
S. Kasamaki
Department of Coloproctological Surgery, Juntendo University School of Medicine
K. Sakamoto
Department of Coloproctological Surgery, Juntendo University School of Medicine
T. Ochiai
Department of Surgery, Tobu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation
I. Nagaoka
Department of Host Defense and Biochemical Research, Juntendo University School of Medicine
T. Kamano
Department of Coloproctological Surgery, Juntendo University School of Medicine

Keywords: Sodium ferrous citrate

JOURNAL FREE ACCESS

2007 Volume 60 Issue 1 Pages 1-7

DOI https://doi.org/10.3862/jcoloproctology.60.1

Details

Abstract

We previously investigated the effects of sodium ferrous citrate (SFC) on neutrophils in vitro and revealed that SFC inhibits neutrophil functions such as oxygen radical production and chemotaxis. In this study, we evaluated the anti-inflammatory effect of SFC using a dextran sulfate sodium (DSS) -induced rat colitis model. DSS solution (5%) was given ad libitum for 10 days to rats (DSS group). SFC (2mg/body) was given per os to SFC+DSS group rats for 3 days before the DSS administration and for 10 days accompanied with DSS solution. Leukocyte count was markedly increased in DSS rats and the increase was significantly suppressed in SFC rats. The length of colon was shortened in DSS rats, but the change was suppressed in SFC rats. The erosion area was significantly smaller in SFC rats compared with that of DSS rats. These findings indicate that SFC has a potential to exert anti-inflammatory actions on a DSS-induced rat colitis model.

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