2010 Volume 63 Issue 2 Pages 43-50
The clinicopathological characteristics of mucinous colorectal carcinoma with curative resection were compared with those of well-moderately differentiated adenocarcinoma as a control. Mucinous colorectal carcinoma was classified into two groups according to the histological characteristics, and the prognostic factors and clinicopathological factors were examined. Mucinous colorectal carcinoma accounts for 5.1% of all primary colorectal cancer. Compared with well-moderately differentiated adenocarcinoma, mucinous carcinoma was found more often in the right side of the colon, with a large tumor size and advanced stage. The 5-year overall survival rates for mucinous carcinoma and well-moderately adenocarcinoma were 68.8% and 80.8%, respectively. Univariate and multivariate analyses identified three factors as independent prognostic features significantly affecting the 5-year overall survival rates in mucinous carcinoma: lymphatic invasion, lymph node metastasis and pathological type (poorly-differentiated type). Patients with more risk factors had a markedly worse 5-year overall survival. Mucinous colorectal carcinoma was classified into two groups according to the histological characteristics. The 5-year overall survival rates for the poorly-differentiated type and the well-differentiated type were 40.0% and 71.8%, respectively. In mucinous colorectal carcinoma, the presence of multiple adverse prognostic factors identifies a high-risk subgroup. Other therapeutic and follow-up plans should be considered between mucinous carcinoma and well-moderately adenocarcinoma.
