Ki-67 Labeling Inex and Survival of the Patients with Colorectal Carcinoma

Abstract

Labeling index (LI) of Ki-67, a nuclear antigen present in proliferating cells, was determined in 56 colorectal cancer by an immunohistochemical technique, and was correlated with recurrence of the disease and survival of patients.
The LI did not correlate with clinical stages of the disease, recurrence rate after curative resection, or survival of the patients.
A potential proliferative activity of tumor cells can be easily determined by measuring Ki-67 labeling index.
The proliferative activity of tumor cells thus determined, however, has little prognostic value for colorectal cancer patients.