Effective γ-Globulin Therapy for an Ulcerative Colitis Case with Selective Ig A Deficiency

Abstract

A 53-years-old female ulcerative colitis patient had complained of mucous bloody stools, was treated as a proctitis type 4 years, and was admitted in April 1993. Since her condition resisted intravenous hyperalimentation and intravenous high dose steroid hormone (SH) therapy and progressed to total colitis type, γ-globulin therapy was attempted. After the therapy, clinical symptoms and colonofiberscopic findings improved.
In this patient, the serum IgA level was normal at the initial examination and after discharge, but selective IgA deficiency was noted during hospitalization after administration of high dose SH. Latent immunological disorders are considered to have been present, and transient selective IgA deficiency is also considered to have been induced by high dose SH.