1996 Volume 49 Issue 1 Pages 43-50
The influence of dietary factors on fecal enzymatic activities of colon cancer induced by DMH was examined. Fecal enzymatic activities were decreased in all stages; in particular, Nitroreductase and Azoreductase activities were significantly decreased in prestage of the cellulose diet (p<0.01). Nitroreductase and Azoreductase activities tended to increase in post-stage of the cholesterol diet. The number of colonic tumors per rat was found, atypical glands were significantly increased in the cellulose diet, and cancers were signifucantly increased in the cholesterol diet. However, size of cancers was not significantly different between cellulose and cholesterol diets. These results suggested that colonic carcinogenesis is related to dietary factors, which are related to fecal enzymatic activities, especially Nitroductase and Azoreductase activities.
