Statistical Analysis of Pathological Factors of Colorectal Cancer For The Prognostic Evaluation by Quantification Theory

Abstract

Colorectal carcinoma has been analyzed to assess quantitative prognostic values of 9 pathological factors and their sub-categories with the aid of a computer. Besides the routine procedure, Hayashi's quantification theory II was used. The relation to 5-year survival was investigated by relative risks. Each score and difference of 5-year survival were investigated and the 5-year survival rate was calculated by using Hayashi's quantification theory II.
With 9 pathological factors, in colonal cancer, caecum, lymphatic invasion, scale of over 51mm, descending colon were strong prognostic variables.
With 9 pathological factors, in rectal cancer, lymphatic and venous invasion, rectosigmoid colon were strong prognostic variables.
The 5-year survival (able or not) is in fact discriminated in 79.4% at the colonal carcinoma with using 4 pathological factors. The 5-year survival (able or not) is also discriminated in 79.4% for rectal carcinoma. On the contrary, the 5-year survival (able or not) is discriminated in 89.3% for the colonal carcinoma with using 9 pathological factors. And the 5-year survival (able or not) is discriminated in 83.8% for rectal carcinoma.
Especially for colonal carcinoma, the statistical analysis (calculating each score) using 9 pathological factors correctly to assess quantitative prognostic values was comparable using 4 pathological factors (p<0.005).